Amyloid β levels in cognitively unimpaired adults predict subsequent cognitive decline


  • In cognitively unimpaired elderly adults, cerebrospinal fluid is more likely to show earliest amyloid β changes than positron emission tomography.

Why this matters

    Almost a third of cognitively unimpaired older adults have biomarker evidence of abnormal amyloid-β pathology as measured by cerebrospinal fluid; however, the role of amyloid β positron emission tomography remains unknown. These novel findings could assist with amyloid β-lowering interventions in the earliest, asymptomatic stages of Alzheimer’s disease.