SummaryShort summary of a recent publication, written by scientific experts.
Published: 01 May 2023
Biomarkers for focal motor weakness in amyotrophic lateral sclerosis – an accurate tool?
In an observational imaging study using fluorodeoxyglucose-positron emission tomography (FDG-PET) to longitudinally assess patients with amyotrophic lateral sclerosis (ALS), a pattern of brain metabolic alterations consistent with previous findings were noted.
The authors concluded that increased hypometabolism and decreased hypermetabolism were markers of higher symptom burden.
Focal motor weakness did not correlate to specific metabolic alterations, suggesting metabolic changes observed via FDG-PET cannot be used as a predictor of focal motor weakness progression.