Blood pressure and early computed tomography perfusion in aneurysmatic subarachnoid hemorrhage

A retrospective study evaluated the relationship between blood pressure and mean transit time (MTT) of early computed tomography perfusion (CTP) imaging within 24 hours of bleeding preceding aneurysm occlusion in 134 patients with aneurysmatic subarachnoid hemorrhage (aSAH).
There was a significant inverse association between mean arterial pressure and MTT in early CTP imaging (correlation coefficient = -0.18), with a stronger inverse association seen when the analysis was restricted to patients with World Federation of Neurological Surgeons grade V aSAH (correlation coefficient = -0.40).
These findings suggest greater disruption of cerebral autoregulation with increasing severity of early brain injury, highlighting the need to maintain blood pressure and prevent hypotension in the early phase of aSAH, conclude the researchers.