Cardiometabolic syndromes as modifiable risk factors for incident Parkinson’s disease dementia

  • 79,622 patients with de novo Parkinson’s disease (PD) were analyzed to determine the effect of cardiometabolic syndromes and depression on the incidence of Parkinson’s disease dementia (PDD).
  • All syndromes analyzed were shown to independently increase the risk of PDD: hypertension (subdistribution hazard ratio [SHR] = 1.11; 95% CI, 1.07–1.16); diabetes (SHR = 1.09; 95% CI, 1.05–1.14); dyslipidemia (SHR = 1.15; 95% CI, 1.11–1.20); depression (SHR = 1.36; 95% CI, 1.30–1.41).
  • Authors concluded that updating public health policies to include the control of cardiometabolic syndromes may be useful for the prevention of PDD in patients with PD.