Chorioretinal fold development observed in astronauts after long duration space flight

  • Little is known regarding the pathophysiology of chorioretinitis during long-duration spaceflight missions.
  • For this study, optical coherence tomography scans revealed chorioretinal folds in 6 out of 36 crew members. Of those individuals with disc edema, 24% had choroidal folds, 10% had inner retinal folds and 5% had peripapillary wrinkles. In addition, 4 of the 6 crew members developed macular choroidal folds (7 of 12 eyes) which worsened over the 6–12 spaceflight duration.
  • Understanding the dynamics behind chorioretinal fold development for missions longer than a year may provide insight to counter the effects of further disease progression.