Deep brain stimulation of the subthalamic nucleus modulates motor-related behavior in people with Parkinson disease

  • Deep brain subthalamic stimulation is an effective treatment for motor symptoms of movement disorders including Parkinson disease (PD).
  • This study followed 27 patients with PD (not on medication) that received deep brain stimulation electrode implants in the subthalamic nucleus. Findings revealed that subthalamic stimulation elicited modulating effects on recovery, relieving, and remodeling. Significant correlations between recovery effects and improvements in tremor and posture symptoms, and restoration of low levels of functionality, all manifested by subthalamic stimulation (P<0.05) were observed among the cases.
  • Evidence from this study provides a deeper understanding on the role of subthalamic stimulation on motor function in people with PD.