Does repetitive nerve stimulation predict long-term outcome of myasthenia gravis?

  • Repetitive nerve stimulation (RNS) testing remains the gold standard for diagnosing myasthenia gravis (MG). However, many studies provide confounding evidence on the diagnostic and prognostic utility of this test in people with MG.
  • Findings from this study revealed a higher sensitivity (71.6%) of RNS for generalized disease compared to ocular MG (38.5%). There was no correlation between compound muscle action potentials (CMAP), acetylcholine receptor autoantibodies and clinical severity at the time of test or follow-up time. In contrast, CMAP decrement significantly correlated with worst recorded clinical status based on a group analysis.
  • According to the authors, RNS testing may not be sensitive enough for MG diagnosis and may not be an ideal tool for long-term outcome prediction.