Evidence on safety of intravenous thrombolysis for ischemic stroke following recent direct oral anticoagulant treatment

  • Recent direct oral anticoagulant (DOAC) treatment (within 48 hours) was associated with lower odds of symptomatic intracranial hemorrhage after intravenous thrombolysis (IVT) compared to those not treated with DOAC (adjusted OR 0.57, CI 0.36–0.92).
  • The authors concluded that, despite guidelines against IVT in patients with ischemic stroke recently treated with DOAC, there is insufficient evidence of harm and potential benefits associated with IVT in this population.