Four CD59 mutations show differential localization in mammalian cells


  • Mutated CD59 does not protect against membrane attack complex (MAC) and mutants that present on the cell surface may have non-MAC interactions.

Why this matters

  • Mutations in CD59 result in Guillian-Barré syndrome-like disease; tracking the molecular consequences of the four CD59 mutations furthers our understanding of the nature of their dysfunction in patients and may help guide future treatments.