Takeaway
The visual network showed reduced density and topological changes in the brain among individuals with clinically isolated syndrome with optic neuritis (CIS-ON), individuals with CIS with non-ON (CIS-nON), and individuals with neuromyelitis optica spectrum disorder (NMOSD) compared with healthy controls.
Why this matters
Individuals recovering from an episode of multiple sclerosis (MS) and NMOSD may experience functional cortical network changes. The results of this research will assist in the understanding of how the visual system responds to specific damage to the visual network pathway. This will provide a better understanding of the pathophysiology of the two disease groups.