Impact of air pollution exposure on pediatric intracellular white matter microstructure


  • There are significant associations between exposure to outdoor particulate matter ≤2.5 μm (PM2.5) and white matter (WM) microarchitecture in children.

Why this matters

  • It is well known that long-term exposure to PM2.5 is associated with adverse nervous system effects; some studies have shown that air pollution is associated with smaller WM surface area in children, but these studies have been conducted in small populations.

  • This study, the first multisite, large-scale U.S. study to find associations between PM2.5 exposure and WM microarchitecture, has important public health implications, suggesting that efforts to limit childhood exposure to PM2.5 should be investigated.