SummaryShort summary of a recent publication, written by scientific experts.
Published: 01 Feb 2023
Rates of antiseizure medication adherence and the associated risk of sudden unexplained death in epilepsy
In this retrospective cohort study of 1,187 participants treated with antiseizure medication (ASM), ASM adherence was categorized as either good (51%), declining (24%), poor (16%), or very poor (9%).
An increased risk for sudden unexplained death in epilepsy (SUDEP) was observed for individuals with declining ASM adherence, with the risk increasing over time (HR 8.43 at 1 year, HR 9.17 at 3 years).
The authors concluded that ASM adherence is a significant challenge in managing epilepsy with half of patients demonstrating some degree of non-adherence. This has negative impacts on patients including a significant increased risk of SUDEP.