Sex differences in brain connectivity and cognition

  • A large cross-sectional study analyzing sex differences in behavioral and imaging data, namely global functional connectivity density at rest, mean water diffusivity, and total cognitive scores, from children aged between 9 and 11 years old.
  • Girls had higher functional connectivity density, lower mean water diffusivity and transverse diffusivity. Age-corrected fluid and total composite scores were also higher in girls than in boys.
  • Total mean brain volume and the proportion of white matter were larger for boys, however, the proportion of gray matter was larger for girls.
  • Authors have suggested that this information could input into the creation of brain developmental trajectory charts, which could be used for future investigations into any impairments in cognition or behavior.