Striatal-cerebellar abnormalities in children with expanded Huntington gene


  • Mutant Huntington protein may affect striatal-cerebellar circuits early in life in children with an expanded Huntington gene.

Why this matters

  • Children with an expanded Huntington gene show striatal hypertrophy as early as the age of 6 despite motor symptoms that do not present for several decades.

  • It is unclear which structures of the brain are involved in compensation for the developmentally abnormal striatum.