The association between neurocognitive decline and comorbidities in persons with HIV: a CHARTER study


  • Neurocognitive decline in persons with HIV (PWH) is closely linked with acquired comorbidities and unrelated to age or antiretroviral therapy (ART).

Why this matters?

  • Although antiretroviral therapy (ART) has increased the life expectancy of PWH, there are concerns over its effects on accelerated neurocognitive decline due to potential ART toxicity, biological ageing, and accumulating comorbidities.

  • It is important to determine the effects of ART and comorbidities on neurocognition as it impacts medical management of HIV.