The association between the severity of cerebral degeneration and amyotrophic lateral sclerosis survival

  • A longitudinal, multicohort study to determine whether the severity of cerebral degeneration is associated with survival in amyotrophic lateral sclerosis (ALS).
  • Evidence of cerebral degeneration is not apparent in ALS on a regular MRI scan; therefore, texture analysis is performed for quantification purposes.
  • Through texture analysis authors observed corticospinal tract degeneration progressed faster in sub-groups of patients with shorter survival.
  • Autocorrelation of the bilateral corticospinal tract could be used as a predictor of survival at 5 years follow-up (hazard ratio =1.28, P=0.005).