Short summary of a recent publication, written by scientific experts.
Published: 06 Mar 2023
The association between the severity of cerebral degeneration and amyotrophic lateral sclerosis survival
- A longitudinal, multicohort study to determine whether the severity of cerebral degeneration is associated with survival in amyotrophic lateral sclerosis (ALS).
- Evidence of cerebral degeneration is not apparent in ALS on a regular MRI scan; therefore, texture analysis is performed for quantification purposes.
- Through texture analysis authors observed corticospinal tract degeneration progressed faster in sub-groups of patients with shorter survival.
- Autocorrelation of the bilateral corticospinal tract could be used as a predictor of survival at 5 years follow-up (hazard ratio =1.28, P=0.005).