The cholinergic basal forebrain as a structural biomarker for Parkinson’s disease

  • Cholinergic basal forebrain volume was found to be a reliable predictor of cholinergic nerve terminal loss. The strongest correlations were noted in the posterior cholinergic basal forebrain and temporofrontal, insula, cingulum, and hippocampal regions.
  • Therefore, the authors concluded that structural imaging of the cholinergic basal forebrain can be used as a reliable marker for regional cerebral vesicular acetylcholine transporter bindings, most notably in the anterior brain.