The role of choroid plexus inflammation in multiple sclerosis progression

  • Compared to healthy controls, individuals with multiple sclerosis (MS) had larger choroid plexus volumes (P<0.001), but this did not change significantly over the course of the trial.
  • Pseudo T2 mapping, a measure of choroid plexus inflammation, revealed no significant changes from baseline during the trial. However, levels of choroid plexus pseudo T2 at baseline were predictive of disability progression (P=0.03).
  • The authors concluded that choroid plexus inflammation should be considered a clinically relevant factor in the progression of MS.