Understanding the pathophysiology and clinical manifestations of new daily persistent headache

  • Limited knowledge exists on the underlying pathophysiological mechanism driving new daily persistent headache (NDPH).
  • Through functional magnetic resonance imaging (fMRI) analysis, this study (n=30 cases with NDPH; n=30 controls) demonstrated that the NDPH group elicited abnormal activation related to whole brain functional connectivity indicative of visual system impairments, compared to the control group. Additionally, no sex differences in brain activity were noted in the NDPH group (all Ps>0.05). 
  • According to the authors, fMRI was effective in identifying abnormal activation of the visual system, a common impairment associated with people with NDPH.