Using a combination therapy approach for the treatment of drug-resistant epilepsy in adults and adolescents

  • This study investigated whether Modified Atkins Diet (MAD) together with standard drug therapy (SDT) results in reduced seizures and improved psychological outcomes in people (n=160; aged 10–55 years) with drug-resistant epilepsy (DRE).
  • At 6 months, seizure reduction of more than 50% was noted in 26.2% in the intervention arm (SDT plus MAD) versus 2.5% in the control group (SDT only). The intervention arm elicited a higher improvement in the quality of life than the control group (mean difference, 9.6; 95% CI 4.3–14.9, P<0.001).   
  • According to the authors, a combination therapy approach to include MAD is effective for reduced seizure frequency and improved behavioral outcomes in people with DRE.